Abstract
Colorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with different degrees of tumor differentiation. The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), interleukin 6 (IL6), interleukin 8 (IL8), macrophage migration inhibitory factor (MIF), soluble Fas (SFAS), soluble Fas ligand (sFASL), transforming growth factor β (TGF), tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), and programmed death ligand 1 (PD-L1). The data of our study show that most of the basic proinflammatory cytokines are involved in the systemic process and their levels do not depend on the level of tissue differentiation. Serum PD-L1 has shown itself to be a promising marker for tumor growth, which depends on the degree of differentiation.
Highlights
Nowadays, it is recognized that inflammation plays an important role in the pathogenesis of cancer
It would be expected to see that a low degree of tumor differentiation produces more stem cell factor, but this was not recorded in our study
Interleukin 8 (IL-8) to IL-6 is involved in the progression of tumor growth and promotes angiogenesis, proliferation, and migration of cancer cells
Summary
It is recognized that inflammation plays an important role in the pathogenesis of cancer. Inflammation associated with tumor growth affects the innate and adaptive, cellular and humoral, local, and systemic immune responses Factors such as host and tumor cytokines, protein inflammatory mediators, tumor cell infiltration, and systemic shift of myelocytes and lymphocytes in the blood are involved. Serum biomarkers cannot reflect tumor inflammation microenvironment; there is a cross-link between local and systemic inflammatory processes, which allows the use of blood as the least invasive way to study the characteristics of the inflammatory response. For these reasons, there is considerable potential in the topic of studying the role of inflammatory factors, their dependence on the stage, histological type, or degree of tumor differentiation. Objective. e objective of this paper is to study the role of inflammatory mediators at different degrees of International Journal of Inflammation differentiation of colorectal cancer adenocarcinoma in patients of the Kazakh population
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