Abstract

Meier et al. (1950) and Shipley and Meyer (1955) demonstrated that glucocorticoids inhibit the formation of granulation tissue in and around subcutaneously implanted cotton pellets. Meyer, Stucki and Aulsebrook (1953) demonstrated that in the rat pregnancy also decreased granulation tissue formation and reduced the injurious effects of formaldehyde on the knee joint synovialis. These results were interpreted as indicative of an increase in the glucocorticoid moiety of the complex of steroids peculiar to pregnancy. Since the first observations of Hench et al. (1949) that cortisone duplicated the effect of pregnancy in alleviating the symptoms of rheumatoid arthritis and the observations that glucocorticoid levels are increased in pregnancy (Venning, 1946; Gemzell, 1953) various organs and organ systems have been suggested as the source of the pregnancy glucocorticoids. There can be little doubt that the adrenal cortex is the main source of the anti-inflammatory agents produced by such stressors as pyrogens,

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