Abstract
Inflammatory Responses Associated with the Induction of Cerebral Malaria: Lessons from Experimental Murine Models
Highlights
Malaria is one the most serious infectious diseases of humans, with,500 million clinical cases annually
Inflammatory responses mediated by cytokines such as TNF [5], IFN-c [6], LT-a [7], and effector cells including CD4+T [8], CD8+T [9,10], NKT [11], and NK cells [12] have been shown to contribute to the development of experimental cerebral malaria (CM) (ECM)
Antibody depletion studies as well as infection of b2-microglobulin2/2 mice demonstrated that CD8+ T cells contribute to the induction of ECM [8]
Summary
Malaria is one the most serious infectious diseases of humans, with ,500 million clinical cases annually. PRBCs have been found to accumulate in brains of susceptible mice during infection. Inflammatory responses mediated by cytokines such as TNF [5], IFN-c [6], LT-a [7], and effector cells including CD4+T [8], CD8+T [9,10], NKT [11], and NK cells [12] have been shown to contribute to the development of experimental CM (ECM).
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