Abstract
Results: Slow or no-reflow was persistent in 14 (60.9%) patients receiving saline, 7 (30.4%) patients receiving adenosine and 1 (4.8%) patient receiving the combination. IC injection with saline did not produce any improvement in TIMI flow (0.9liO.2 to 1.13kO.3, p=O.574). However, IC injection with adenosine produced improvement in TIMI flow (1.09iO.Z to 2.04*0.3, p=O.O159) and IC injection with combination also resulted in improvement of TIMI flow (0.67iO.2 to 2.6leO.2, p<O.OOOl). Treatment of slow or noreflow in saline group of patients by crossover with combination was associated with reestablishment of TIMI II in 1 (7.1%) and TIMI III in 13 (92.9%) patients. In case of adenosine group of patients the treatment by crossover with combination was associated with reestablishment of TIMI II flow in 2 (28.6%) and TIMI Ill in 5 (71.4%) patients. No untoward complications were noted during the drug administrations. Conclusions: Eventhough IC administration of adenosine produces improvement in TIMI flow, but the number of patients with no-reflow after prophylactic administration of drugs was minimum in case of combination. Thus, IC administration of combination of adenosine and sodium nitroprusside acts better as compared to adenosine administered &Xle.
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