Inflammatory pseudotumor in the submandibular region: A case report with immunohistochemical findings

Abstract

Background: Inflammatory pseudotumor is a rare, benign non-neoplastic lesion. Clinically it behaves as an aggressive lesion, which can be mistaken for malignant tumor. Case presentation: This article presents a rare case of submandibular inflammatory pseudotumor in a 44-year-old man patient. The submandibular mass presented rapid enlargement in one month’s duration after initial examination. The patient was treated with surgery. Histologic examination of the resected specimen showed florid myofibroblastic and fibrohistiocytic proliferations in an inflammatory background. Immunohistochemically, the cells expressed vimentin, α-smooth muscle actin and CD68 indicating a diagnosis of inflammatory pseudotumor. The patient had an uneventful postoperative recovery and no evidence of recurrence. Conclusions: We report a case of inflammatory pseudotumor occurring at the site of submandibular region.