Abstract
Abstract Funding Acknowledgements Type of funding sources: None. As a common factor of both acute coronary syndrome (ACS) and chronic obstructive pulmonary disease (COPD), circulating biomarkers of inflammation may provide a link between these two diseases. The objective of this study was to explore the inflammatory profile of patients with COPD and ACS. 94 men with COPD according to GOLD criteria in stable clinical condition; are included prospectively in the study. Patients was divided into two groups with ACS and without ACS. The levels of circulating CRP, TNF-α and IL6 were determined for both groups. The results showed that circulating biomarkers of inflammation are higher in the group of COPD patients with associated ACS. The rate of CRP g / l: 8.79 ± 17.12VS 8.83 ± 13.09 in the absence of ACS, TNFα pg / ml: 14.99 ± 28.88VS13.01 ± 16.40 and IL6 pg/ml: 32.66 ± 79.12 VS 23.79 ± 37.99. Circulating cytokines are significantly associated with ACS, particularly the level of IL-6, which correlates with the presence of ACS in COPD. These results confirm the association between ACS and chronic inflammation of COPD. And that inflammation and more particularly circulating IL-6 seem strongly implicated in the pathophysiology of atherosclerotic remodeling in the COPD patient with ACS.
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