Inflammatory markers before and after farrowing in healthy sows and in sows affected with postpartum dysgalactia syndrome

Marianne Kaiser,Damián Escribano,Jan Dahl,José Joaquin Cerón,Pia Haubro Andersen,Stine Jacobsen,Magdalena Jacobson,Poul Bækbo

doi:10.1186/s12917-018-1382-7

Abstract

BackgroundThe pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs. Accurate and timely diagnosis is difficult, and PDS is often recognized with a delay once piglets begin to starve. Increased rectal temperature of the sow is an important diagnostic parameter, but it may also be influenced by a number of other parameters and is thus difficult to interpret. Inflammatory markers may be important adjuncts to the clinical assessment of sows with PDS, but such markers have only been studied to a limited extent. The objective was to characterize the inflammatory response in healthy sows and in sows suffering from PDS, and to identify biomarkers that may assist in early identification of PDS-affected sows.ResultsThirty-eight PDS-affected (PDS+) and 38 healthy (PDS-) sows underwent clinical examination and blood sampling every 24 h, from 60 h before the first piglet was born to 36 h after parturition. In both groups, inflammatory markers changed in relation to parturition. Most inflammatory markers changed 12-36 h after parturition [white blood cell counts (WBC), neutrophil counts, lymphocyte counts, tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin (Hp), iron (Fe) and albumin (ALB)]. Changes in neutrophil counts, lymphocyte counts, CRP, Fe and ALB were observed -12 to 0 h before parturition. WBC, neutrophil and lymphocyte counts, serum concentrations of TNF-α, IL-6, Hp and Fe differed between PDS+ and PDS- sows. These differences were mainly apparent 12 to 36 h after parturition, but already at 12 h before parturition, PDS+ sows had lower lymphocyte counts than PDS- sows.ConclusionsParturition itself caused significant inflammatory changes, but PDS+ sows showed a more severe response than PDS- sows. WBC, neutrophil and lymphocyte counts, and concentrations of TNF-α, IL-6, Hp and Fe can be potential biomarkers for PDS. Lymphocyte counts may be used to detect PDS at pre-partum. To assess their diagnostic potential, these markers must be investigated further and most likely combined with assessment of clinical parameters and other biomarkers for improved identification of sows at risk of developing PDS.

Highlights

The pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs
Reduced appetite was observed in 10 PDS+ sows and 5 PDSsows at 0-12 h, while 12 PDS+ sows and 12 PDSshowed reduced appetite at 12-24 h
Inflammatory markers Change in level of inflammatory markers in relation to parturition In both PDS+ and PDS- sows, inflammatory markers changed in relation to parturition

Summary

Introduction

The pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs. Postpartum dysgalactia syndrome (PDS) is a common disease in sows with recently reported prevalences varying from 6.0 to 48.2% [1,2,3,4]. A subgroup of sub-clinically affected sows, which are difficult to detect in the early stages of the disease, seems to occur. These cases of PDS may only be discovered once piglets start to lose weight and display milk-searching behaviour. Increased prevalence of stillborn piglets has been found in litters from sows with fever or elevated rectal temperature before [9] and after farrowing [10]. The impact of PDS on the welfare of sows and piglets is substantial

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