INFLAMMATORY MARKERS AND HYPERTENSION-MEDIATED ORGAN DAMAGE IN COMMUNITY-DWELLING ELDERLY INDIVIDUALS: THE NORTHERN SHANGHAI STUDY

Abstract

Objective: Inflammation plays a role in pathogenesis of atherosclerosis. Many inflammatory makers have proven to can predict cardiovascular events. This study is investigating the association between inflammatory makers and hypertension-mediated organ damage. Design and method: 2451 participants who had available blood routine examination from the Northern Shanghai Study were included in this analysis. Inflammatory makers include white blood cell (WBC), neutrophile, monocyte and monocyte to high-density lipoprotein cholesterol ratio (MHR). Hypertension-mediated organ damage (HMOD), including left ventricular hypertrophy (LVH), arterial stiffness (AS), lower extremity atherosclerotic (LEA), carotid hypertrophy (CH), micro-albuminuria (MAU) and chronic kidney disease (CKD), were measured by standard methods. Logistic regression model was used to explore the relationship between the quartiles of inflammatory makers and HOMD. Results: In multivariable logistic regression analysis, set quartile 1 (Q1) as reference, quartile 4 (Q4) of WBC (odds ratio (OR) = 1.72, 95% confidence interval (CI): 1.31–2.24, Pfor trend < 0.001), neutrophile (OR = 1.48, 95%CI:1.14–1.94, Pfor trend = 0.005), monocyte (OR = 1.37, 95%CI:1.05–1.77, Pfor trend = 0.026) and MHR (OR = 1.41, 95%CI:1.05–1.88, Pfor trend = 0.036) were associated with AS; Q4 of WBC (OR = 1.78, 95%CI:1.24–2.58, Pfor trend = 0.001), neutrophile (OR = 2.06, 95%CI:1.40–3.02, Pfor trend < 0.001), monocyte (OR = 1.64, 95%CI:1.11–2.38, Pfor trend = 0.013) and MHR (OR = 2.23, 95%CI:1.49–3.35, Pfor trend < 0.001) were associated with LEA; Q4 of WBC (OR = 1.60, 95%CI:1.13–2.27, Pfor trend = 0.012), neutrophile (OR = 1.74, 95%CI:1.21–2.51, Pfor trend = 0.002), monocyte (OR = 1.71, 95%CI:1.18–2.46, Pfor trend = 0.013) and MHR (OR = 2.46, 95%CI:1.60–3.77, Pfor trend < 0.001) were associated with CKD; Q4 of monocyte (OR = 0.69, 95%CI:0.54–0.87, Pfor trend < 0.001) and MHR (OR = 0.61, 95%CI:0.47–0.79, Pfor trend < 0.001) were inversely associated with MAU; but no inflammatory markers associated with LVH or CH. Conclusions: In Chinese community-dwelling elderly individuals, WBC, neutrophile, monocyte and MHR are significantly and independently associated with an increased risk of AS, LEA and CKD; monocyte and MHR inversely associated an increased risk of MAU.