Abstract
This study quantitatively examined the effects of monopolar radiofrequency (RF) treatment on the progressive nanostructural changes in the inflammatory effect of in vivo rabbit dermal collagen fibrils during postoperative 7 days. Conventional histologic analysis and atomic force microscopy (AFM) were employed to assess the nanostructural dermal response in 6 RF groups that underwent 2 passes of RF treatments (10 and 20 W), and 1 untreated control rabbit. After monopolar RF treatment, the rabbit skin clearly showed changes in the collagen network structure. The RF-treated group showed regular parallel arrangement of collagen fibrils whereas normal group showed tangled nanostructures. This phenomenon was remarkable at postoperative 7 days. Therefore, monopolar RF treatment leads to underlying collagen contracture and promotes new collagen formation. A multi-pass treatment of low-energy RF led to the highest contraction of collagen fibrils at the nanostructural level, compared to a single pass of high-energy RF.
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