Abstract
Inflammatory damage during both shock wave and intracorporeal laser lithotripsy
Highlights
Acute kidney injury (AKI) is a syndrome characterized by a rapid decrease in renal excretory function, which causes the accumulation of many nitrogen metabolism-derived products, among of which creatinine and urea stand out because they are clinically measured
We think that it may be important to review the current knowledge in the field of lithotripsy with aims to understand the inflammatory process behind such a therapeutic approach, as it may serve the purpose of enhancing awareness about its potential to produce AKI and chronic kidney disease (CKD), but it may be of use to pinpoint the need to investigate new combinatorial therapeutic approaches that may limit inflammatory damage by this necessary, and currently irreplaceable, therapy
Nephrolithiasis is an increasingly common disease that is very diverse in its clinical presentations, which compels the use of different clinical approaches
Summary
Acute kidney injury (AKI) is a syndrome characterized by a rapid (hours to days) decrease in renal excretory function, which causes the accumulation of many nitrogen metabolism-derived products, among of which creatinine and urea stand out because they are clinically measured. Health practitioners may be unaware of some of the etiological entities that may induce a certain degree of AKI that could progress to CKD, as both conditions are vastly understudied and not entirely understood This phenomenon, in part, is due to the lack of animal models that are truly representative of the human pathology, and because its study in humans depends upon biopsies taken from cadavers, that already have suffered a death-derived ischemia [4,6]. We think that it may be important to review the current knowledge in the field of lithotripsy with aims to understand the inflammatory process behind such a therapeutic approach, as it may serve the purpose of enhancing awareness about its potential to produce AKI and CKD, but it may be of use to pinpoint the need to investigate new combinatorial therapeutic approaches that may limit inflammatory damage by this necessary, and currently irreplaceable, therapy
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