Abstract
Obstructive coronary artery disease (CAD) is characterized by inflammation within the atherosclerotic coronary arteries. Infiltration of inflammatory cells into muscular media can lead to remodeling and weakening of the arterial wall. We examined the relationship between inflammatory infiltration in perivascular adipose tissue (PVAT), state of the external elastic membrane, and the intensity of inflammatory infiltration in the tunica media of coronary arteries obtained by endarterectomy from symptomatic patients with diffuse CAD. We analyzed endarterectomy sequesters from 22 coronary arteries that contained the intima, media, a part of the adventitia, and PVAT in at least one part of the sequester. The coronary arteries were divided into two groups according to the presence or absence of inflammatory infiltration in PVAT. Staining with hematoxylin-eosin and by the Movat’s method showed atherosclerotic changes in the intima and media. Immunohistochemistry (anti-leukocyte common antigen [LCA] antibody) was used for the detection of leukocytes. We found a significant positive correlation between inflammatory infiltration in PVAT and preservation of the external elastic membrane of coronary arteries. Furthermore, we found a significant negative correlation between inflammatory infiltration in PVAT and the intensity of inflammatory infiltration in the media. It seems that the integrity of the external elastic membrane and the proinflammatory properties of PVAT restrain inflammatory cells within PVAT. Both effects may prevent the migration of inflammatory cells into the media and delay the development of CAD.
Highlights
Coronary artery disease (CAD) is characterized by inflammation within the atherosclerotic coronary vessel wall [1,2,3]
The tunica intima and, partly, the tunica media were the focus of research, and perivascular adipose tissue (PVAT) that surrounds coronary arteries (CAs) was considered to be passive and only supportive tissue
We showed that inflammatory infiltration in PVAT negatively affects the intensity of inflammatory infiltration in the media of CAs
Summary
Coronary artery disease (CAD) is characterized by inflammation within the atherosclerotic coronary vessel wall [1,2,3]. The tunica intima and, partly, the tunica media were the focus of research, and perivascular adipose tissue (PVAT) that surrounds coronary arteries (CAs) was considered to be passive and only supportive tissue. It has become evident that PVAT has a crucial role in maintaining the normal function of CAs [4,5,6], and that it is involved. Submitted: 07 August 2019/Accepted: 12 September 2019
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