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Abstract
Inflammatory breast cancer (IBC) is a highly aggressive and radiation resistant breast cancer that continues to have a dismal prognosis despite aggressive multimodality therapy, which includes ionizing radiation (IR). We recently showed that the unique pathogenic properties of IBC result in part from over-expression of the translation initiation factor eIF4G, which promotes IBC tumor cell survival, formation of tumor emboli and metastasis. We also demonstrated that protein synthesis is highly regulated during IR by the DNA-damage response (DDR) pathway through mTOR.
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