Inflammatory breast cancer in Manizales from a developing country like Colombia

Abstract

11573 Background: Inflammatory breast cancer is one of the worst cancers in the world and for developing countries it seems to have the same prognosis; we studied this specific group for knowing its behavior in the Instituto Oncologico ION S.A., Manizales. Methods: It begins with a retrospective analysis from our cancer records in order to extract this specific breast cancer population. Results: The group accrued 888 breast cancer patients from January 1995 to December 2006 with 52 (5.85%); 100% female; median age 55 (range 25–93 SD:12.743); urban area 100%; clinical symptom was mass (71%), best diagnoses method was test by themselves (93%), second neoplasia in 4% with contralateral breast cancer (100%), ductal carcinoma (98%), RE(+) 23%, RP(+) 19% and HER(+) 6% in only 10% of the patients, invasion lymph-vascular (+) 43%, MRM surgery 58%, conservative surgery 8%, mean resected nodes 11 and mean positive resected nodes 7, familiar first degree antecedent 4%, postmenopausal stage 60%, right breast 40%, CSE localization 31%, initial chemotherapy (QT) scheme FAC 60%, AC 23% CMF 4%; 27% changed initial QT because of bad pathologic response in 18% and without clinical response with initial QT 10%; radiotherapy (RT) boost 8%; mean tamoxifen therapy 12 months (range 1 to 84 months SD: 20.087) and 17% patients received a second hormone therapy because of relapse; general complications 14% like hematologic (55%); neoadjuvant treatment 64% with QT (94%) and adjuvant treatment 58% based of QT and RT (80%); global relapse (40%) with bone (28%), scar (19%), lung (10%), skin (13%), CNS (16%) and liver (3%) mean follow-up of 34 months (SD: 27.247) and overall survival by Kaplan-Meier at 5 years for breast cancer was 48.4% (95% CI: 57.2–72.2). Conclusions: This is the inflammatory breast cancer group in our population and we think that it is not different from other specific results from other cancer groups. No significant financial relationships to disclose.