Abstract
The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients.
Highlights
Fibromyalgia (FM) is characterized by chronic widespread pain of more than 3 months duration [1]
We highlighted the effects of a single acute session of Whole body vibration (WBV) on improving the inflammatory status in patients with FM, redirecting parameters towards metabolic homeostasis, and reaching values close to those of anthropometric parameter and age-matched HW at their basal status
This is the first study that investigated the effects of an acute WBV stimulus on the inflammatory response in women with FM
Summary
Fibromyalgia (FM) is characterized by chronic widespread pain of more than 3 months duration [1]. Tumor necrosis factor (TNF) is another potent cytokine, secreted mainly by macrophages, with mostly proinflammatory and catabolic actions, together with high levels in the serum of FM subjects [3]. This marker has soluble receptors (sTNFR1 and sTNFR2) which compete with the surface receptor by binding to TNF and modulating its inflammatory activity, and it has been suggested that they function as physiological attenuators of the degradative activity of TNF [4]. Whereas the soluble receptors are generally more stable in the circulation than the cytokines, the former can be more reliable markers of chronic inflammation [5]
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