Inflammatory and hemostatic abnormality in atrial fibrillation patients at tertiary care hospital, Mardan

Abstract

Objective: To determine the levels of C-reactive protein (CRP) and D-dimers in patients presenting with atrial fibrillation. Study design: Descriptive Cross sectional/Observational. Place and duration of study: From Januarty 2019 to June 2020, the study was carried out in the cardiology and pathology departments of Mardan Medical Complex and Bacha Khan Medical College Mardan. Material and Methods: This study included a total of 100 patients with atrial fibrillation, with 50 people serving as the control group. The levels of CRP and D-dimers were determined in all cases. Results: 35% of the individuals in this study had increased CRP levels. The average CRP level was 2.99 +/- 0.652mg, which was substantially higher than in the control group. Similarly, 45% of patients had an increased D-dimer level. Among these individuals, 30% had D-dimer levels between 250 and 500mg, and 50% had levels between 500 and 1000 ng/ml, which were considerably higher than the control group. Conclusion: According to the findings of the study, atrial fibrillation is related with both inflammatory and coagulation abnormalities, as seen by higher CRP and D-dimer levels. Both these indicators are thromboembolic risk factors.