Inflammatory and aerobic fitness discrimination of Metabolic Syndrome Patients

Abstract

Inflammatory and aerobic fitness discrimination of Metabolic Syndrome Patients Franz H. P. Burini, Avany F. Pereira, Roberto C. Burini CeMENutri - UNESP, SP, Brazil; PRONUT - USP, SP, Brazil Metabolic Syndrome (MS) is a major cardiovascular risk factor, and has been associated with others risk factors, such as pro-inflammatory status and low cardiorrespiratory fitness (VO2max.). Little is know about the influence of inflammatory markers on VO2max., and the influence of MS in this relationship. PURPOSE: To evaluate the influence of pro-inflammatory status in VO2max., and its relation with Metabolic Syndrome. METHODS: We assessed 158 subjects (44 males and 144 females; 54 ± 9 years of age), for plasma biochemistry (including hs-CRP, HDL-cholesterol, glucose and triglycerides), clinical evaluation (vital signs) and cardiorrespiratory fitness - VO2max. (treadmill stress test by Balke protocol). For MS diagnosis we used ATP III (NCEP, 2001) criteria. All subjects were participants (volunteers) in a lifestyle changing program and an informed consent was obtained. Value comparisons were made using t Student test, adopting 5% as significance level. RESULTS: Pro-inflammatory status discriminated VO2max. (hs-CRP P25 vs P75: 37.6 ± 12.2 vs 32.5 ± 11.1 mL-1.kg-1.min-1) whereas in the higher pro-inflammatory status group (hs-CRP P75), MS patients showed lower VO2max. (27.3 ± 12.1 vs 34.9 ± 10.3 mL-1.kg-1.min-1). CONCLUSIONS: We suggest that high VO2max. is associated with low hs-CRP; and MS patients with high hs-CRP should focus their treatment on non-drug strategies, such as physical activity.