Abstract
Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases. The aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of young adults. Subjects from a population-based birth cohort with a mean age of 22.5 years were included in the study population (n = 2074). Protein levels were analyzed using the Olink Proseek Multiplex Inflammation panel. Percentage body fat (%BF) and visceral fat rating (VFR) measurements were collected using Tanita MC 780 body composition monitor. Linear regression of standardized values was used to investigate associations. Potential effect modifications by sex and BMI category were assessed. Of 71 investigated proteins, 54 were significantly associated with all adiposity measurements [%BF, body mass index (BMI), VFR and waist circumference]. Among proteins associated with %BF, seven showed a larger or unique association in overweight/obese subjects and three showed a significant effect modification by sex. Fourteen proteins more strongly associated with VFR in females compared to males. Adipose-associated systemic inflammation was observed in this young adult population. Sex and adiposity localization influenced some of the associations. Our results highlight specific proteins as suitable biomarkers related to adiposity.
Highlights
Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases
In our population-based study of young adults, we show that adiposity reflects in a systemic inflammatory protein profile
Some of the proteins demonstrated a more marked positive association with %BF in overweight/obese subjects, suggestive of an accelerated release of these factors with increasing body mass index (BMI), possibly promoting a chronic inflammatory state that has previously been related to increased risk of cardiometabolic disease d evelopment[3]
Summary
Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases. The aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of young adults. Of 71 investigated proteins, 54 were significantly associated with all adiposity measurements [%BF, body mass index (BMI), VFR and waist circumference]. Weight change and body mass index (BMI) have been associated with several inflammation-related proteins in studies utilizing proteomic methods in cohorts of overweight and obese p articipants[15,16,17]. How adiposity measurements associate with a large panel of inflammation-related biomarkers in a young population including both normal and overweight subjects has not been previously studied. The primary aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of normal- and overweight/obese young adults. The secondary aim was to assess interaction between body fat and sex regarding association with inflammationrelated protein levels
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