Abstract
Depression is one of the most common psychiatric disorders. Animal models represent a valuable research tool to investigate the molecular pathogenic mechanisms of depression and to develop and test different possible antidepressant drugs. Therefore, several murine models have been established, but the chronic unpredictable mild stress model has robust evidence. Inflammation and oxidative stress pathways have a clear involvement in the complex and intricate pathophysiology of depression, with strong evidence coming from studies using the chronic unpredictable mild stress model. This review provides an overview of the characteristics of the chronic, unpredictable mild stress model of depression and its role in investigating inflammation and oxidative stress pathways in depression.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.