Inflammation, Overweight, Obesity and HLA Gene: The Evidence Based on 1.377 Million Healthy Chinese Adults

Abstract

After obtaining the authorization approval of the journal, the original article entitled HLA-B*07, HLA-DRB1*07, HLA-DRB1*12, and HLA-C*03: 02 Strongly Associate With BMI: Data From 1.3 Million Healthy Chinese Adults. , published in Diabetes Volume 67, May 2018: 861-871, written by Shen J, Guo T, et al. have been translated into Chinese by us. Background Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. Method HLA genotyping has been carried out in more than 1.377 million healthy adult donors fromthe Chinese Marrow Donor Program (CMDP) for analyze the association of HLA alleles with BMI. Results Total 23 HLA alleles, including 12 low-resolution and 11 highresolution alleles, were significantly associated with BMI. After correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B*07, DRB1*07, DRB1*12, and C*03: 02 provided the strongest associations with BMI (P=6.89×10-10, 1.32×10-9, 1.52×10-9, and 4.45×10-8, respectively), where B*07 and DRB1*07 also had evidence for sex-specific effects (Pheterogeneity=0.006 7 and 0.000 58, respectively). Conclusion In summary, the results of this study suggest that specific HLA alleles are associated with higher or lower BMI in human populations and that these alleles may cause alterations in obesity risk through their roles in immune responses. (Chin J Endocrinol Metab, 2018, 34: 968-975)