Abstract
Inflammation induced by very low-dose bisphenol-a can be prevented by probiotics
Highlights
In Western countries, the prevalence of obesity, metabolic syndrome, diabetes, allergies, autoimmune diseases and inflammatory bowel disease (IBD) is rapidly increasing [1,2,3,4,5,6]
Transepithelial electrical resistance (TEER) of Caco2 cells, a colon carcinoma cell line that can be differentiated into intestinal epitheliallike cells, is a good marker of barrier integrity
We have revealed that BPA at 0.1 nM and 1 nM significantly decreases TEER and deregulates tight junctions (TJs) integrity, accompanied by decreased Caco2 monolayer thickness
Summary
In Western countries, the prevalence of obesity, metabolic syndrome, diabetes, allergies, autoimmune diseases and inflammatory bowel disease (IBD) is rapidly increasing [1,2,3,4,5,6]. These conditions are most likely caused by the complex interaction between genetic susceptibility; immune deregulation driven by a response to commensal flora; and pharmacological, psychological and dietary factors [7,8]. Humans are chronically exposed to BPA, which first contacts the intestinal epithelium
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