Inflammation in Health and Disease: Novel Therapeutic Approaches

Abstract

Inflammation, which is regarded as an innate immune mechanism, is a part of the intricate biological reactions of a tissue to injury that shield the organ by eliminating harmful stimuli and starting the healing process. The majority of non-steroidal anti- inflammatory medications on the market work well for inflammatory diseases. Several compounds that disrupt the inflammatory response have also been identified in Indian Medicinal Plants (IMP). The multitude of side effects associated with the anti-inflammatory medications now on the market has a negative impact on human well-being. Advent of novel anti-inflammatory therapies such as herbal preparations, recent developments in the use of bioactive ingredients from herbal remedies to treat osteoarthritis and in the application of synthetic COX-2 inhibitors, chitosan as a therapy for oral mucosal irritation, improvement in the medication used to treat acute pancreatitis, extracellular vesicles from mesenchymal cells for the therapy of inflammation, oral colonic drug delivery methods for treating inflammatory bowel disease and combined targeting therapy for inflammatory bowel management will not only effectively manage the inflammation and its associated disorders but also helps to significantly improve the quality of life. Hence the current review reveals the recent advances in the field of inflammation and anti-inflammatory activity in detail.