Abstract
Background: In most healthy individuals, blood pressure (BP) shows a circadian rhythm. Being non-dipper increases cardiovascular risk in normotensive and hypertensive individuals. Nocturnal dipping shows a correlation with the state of inflammation. Objetive: To investigate the relationship between inflammation-based indexes and nocturnal BP pattern in normotensive individuals. Method: This is a retrospective study that included patients evaluated with ambulatory BP monitoring (ABPM). A total of 131 normotensive individuals were included and grouped as dippers and non-dippers. The normality of [...]
Highlights
Blood pressure (BP) normally decreases during sleep, and certain metabolic and cardiovascular alterations may affect this circadian pattern.[1]
Significant negative correlations were observed between the change in systolic blood pressure (BP) [ΔSBP] and systemic immune-inflammation index (SII) (r=-0.172, p=0.049) and between ΔSBP and platelet to lymphocyte ratio (PLR) (r=-0.179, p=0.040)
SII is a predictor of nocturnal BP pattern in normotensives
Summary
Blood pressure (BP) normally decreases during sleep, and certain metabolic and cardiovascular alterations may affect this circadian pattern.[1] Leading reasons for a non-dipping BP pattern are obesity, sleep disorders, obstructive sleep apnea, chronic kidney disease, excessive salt consumption, diabetes mellitus, orthostatic hypotension, autonomic dysfunction, and advanced age.[2] An arbitrary cut-off point has been proposed to define patients as “dippers” if their nocturnal BP falls by. ≥10% of the daytime mean BP value.[2] A non-dipper BP pattern is associated with high cardiovascular mortality and morbidity in people with both normal BP and hypertension.[3,4]. Being non-dipper increases cardiovascular risk in normotensive and hypertensive individuals. Objetive: To investigate the relationship between inflammation-based indexes and nocturnal BP pattern in normotensive individuals
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