Year-end Sale % OFF 
Abstract
BackgroundTo evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines.MethodsForearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-α and IL-6) and adiponectin were also determined.ResultsFSBF is significantly reduced in GDM group compared with control subjects (344.59 ± 57.791 vs.176.38 ± 108.52, P < 0.05). Among all subjects, FSBF showed a strong negative correlation with TNF-α and IL-6 (r = −0.426, P < 0.0001 and r = −0.564, P < 0.0001, respectively) and positive correlation with adiponectin (r = 0.468, P < 0.0001).ConclusionsEndothelial function, an early marker of macrovascular disease, is present in non-obese pregnancies complicated by GDM. This alteration seems to be directly related to inflammatory status, which may represent a patho-physiological link between GDM and type 2 diabetes and, later on, metabolic syndrome.
Highlights
Gestational diabetes mellitus (GDM), is one of the most commonly observed obstetrical complications affecting from 5% to 8% of all pregnancies [1,2].gestational diabetes mellitus (GDM) is associated with the development of inflammation [3], where adipose tissues play an important role in the regulation of insulin sensitivity by secreting adipokines which are involved in the pathogenesis pregnancy-induced insulin resistance, in the case of obese pregnancies [4,5,6]
Many studies suggest that GDM is characterized by the installation of subclinical inflammation associated with a vascular dysfunction due to the insulin resistance, but to date there has been a dearth of studies, evaluating cytokine levels in women with GDM in order to explain their contribution to endothelium dysfunction [7]
Glucose at fasting, Homeostasis model assessment-insulin resistance (HOMA-IR) and Glycated hemoglobin (HbAc) were significantly higher in GDM group compared to control, whereas fasting insulinemia was insignificantly increased in GDM group
Summary
Gestational diabetes mellitus (GDM), is one of the most commonly observed obstetrical complications affecting from 5% to 8% of all pregnancies [1,2].GDM is associated with the development of inflammation [3], where adipose tissues play an important role in the regulation of insulin sensitivity by secreting adipokines which are involved in the pathogenesis pregnancy-induced insulin resistance, in the case of obese pregnancies [4,5,6]. Many studies suggest that GDM is characterized by the installation of subclinical inflammation associated with a vascular dysfunction due to the insulin resistance, but to date there has been a dearth of studies, evaluating cytokine levels in women with GDM in order to explain their contribution to endothelium dysfunction [7]. Non-invasive measurement of microcirculatory blood flow in patients has recently emerged as useful tool to investigate the effect of insulin resistance on endothelial function [8,9]. We have conducted the present study to assess whether non-obese GDM women present an impairment of endothelial NO release; we wanted to focus us on the only effect of diabetes on the inflammatory status and its impact on endothelial function. To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
