Abstract
After the analysis of data presented in the international literature there are still a lot of controversial issues on the impact of inflammation on the development of colon cancer. Molecular mechanisms of various types of colorectal cancer are different and connected with inflammatory bowel diseases. There are some immunological similarities and differences between colitis-associated colon cancer occurring in inflammation and other types of colorectal cancer developing without any signs of inflammatory process. The gut microbiota significantly influences on the development of sporadic colorectal cancer and colitis-associated cancer. Malignant colon tumors, without dependence on the colorectal cancer type, have an increased expression of pro-inflammatory cytokines. The role of tumor-infiltrating immunocytes and tumor inflammatory microenvironment in colorectal cancer is complex: they are involved in antitumor immune defense and play a pro-oncogenic role. In perspective anti-inflammatory biologic drugs are expected to decrease the risk of the development of colorectal cancer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
