Abstract
Bone remodeling is a physiological process determined by the sequential and coordinated interaction involving osteocytes, osteoclasts and osteoblasts, as well as inflammatory cells and mediators. This balance between osteoblastic bone formation and osteoclastic resorption is disrupted during chronic inflammation, leading to local and systemic changes in bone architecture and quality. In this review, the influence of chronic inflammation is explored during physiological bone remodeling and during a set of four chronic inflammatory associated pathologies: rheumatoid arthritis, spondylarthropathies, periodontitis, and postmenopausal osteoporosis.
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