Inflammation and autoimmune responses are independent of peripheral MHC class II expression driven by CIITA pIV in collagen induced arthritis

Abstract

BackgroundIn rheumatoid arthritis (RA), non-professional antigen presenting cells (APCs) such as fibroblast-like synoviocytes (FLS) can express MHC class II (MHCII) molecules and function as non-professional APCs in vitro.ObjectiveTo examine the...