Abstract
Inflammasomes are intracellular protein complexes participating in the activation of inflammatory cytokines IL‐1b and IL‐18 as well as in the induction of pyroptosis. NLRP3 inflammasome is the most well‐known inflammasome type, and its functionality in retinal pigment epithelium (RPE) cells has been known since 2012. We have learned in 10 years that inflammasome activation in human RPE cells can result into the release of either IL‐1b or IL‐18 and even if released concurrently, they can be regulated by different pathways. Time and apparently also the route for the secretion of IL‐1b from RPE cells differs from that of macrophages. NLRP3 inflammasome can be activated by different mechanisms, and the activation mechanism depends on local conditions in a cell. Recent studies have shown that several inflammasome types can be activated in same cells, and full inflammasome activity may need co‐operation of different caspases although caspase‐1 is the predominant player upon inflammasome activation.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
