Abstract
Background and Objectives: Early vascular aging determines a more rapid course of age-related arterial changes. It may be induced by a proinflammatory state, caused by hyperuricemia and metabolic syndrome and their interrelationship. However, the impact of serum uric acid (SUA) on early arterial stiffening and vascular function remains uncertain. Materials and Methods: A total of 696 participants (439 women aged 50–65 and 257 men aged 40–55) from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program were enrolled in the study. They underwent anthropometric measurements and laboratory testing along with arterial parameters’ evaluation. Quality carotid stiffness (QCS), carotid-radial pulse wave velocity (crPWV), carotid-femoral pulse wave velocity (cfPWV), flow-mediated dilatation (FMD), and carotid intima-media thickness (CIMT) were registered. Results: We found that hyperuricemia was significantly associated with inflammation, registered by high-sensitivity C-reactive protein in both sexes. A very weak but significant association was observed between cfPWV and SUA in men and in women, while, after adjusting for risk factors, it remained significant only in women. A positive, weak, but significant association was also observed for QCS, both right and left in women. No relationship was observed between crPWV, FMD, CIMT, and SUA.
Highlights
The concept of early vascular aging (EVA) describes individuals with accelerated age-related vascular remodeling and dysfunction compared to expected aging
fasting plasma glucose (FPG) and the inflammation process, defined by high-sensitivity C-reactive protein (hs-CRP), had no significant difference between the sexes
Lithuanian cohort with metabolic syndrome, even “normal” levels of serum uric acid are associated with inflammation, higher mean arterial pressure, and stiffer arteries measured by aortic stiffness
Summary
The concept of early vascular aging (EVA) describes individuals with accelerated age-related vascular remodeling and dysfunction compared to expected aging. The recent concept of inflammaging is understood as an age-related condition observed when sterile, low-grade, chronic inflammation is present [2,3] It explains why patients with rheumatoid arthritis, inflammatory bowel disease, uremia [3], and other conditions related to persistent inflammation, e.g., metabolic syndrome [4], present increased arterial stiffness [5] and, thereby, higher cardiovascular risk [2]. On the other hand, remains significant in today’s world It is considered as a proinflammatory state; it, may be associated with EVA and, with increased cardiovascular disease (CVD) risk [6]. Materials and Methods: A total of 696 participants (439 women aged 50–65 and 257 men aged 40–55) from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program were enrolled in the study They underwent anthropometric measurements and laboratory testing along with arterial parameters’ evaluation. No relationship was observed between crPWV, FMD, CIMT, and SUA
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