Abstract
Solitary benign angiolipoma and infiltrative angiolipoma are rare tumours in dogs. Angiolipomata can be distinguished histologically from lipomata by the large number of tightly packed blood vessels seen between the adipocytes with multiple fibrin thrombi occupying some of the vessels' lumens. The dog presented with a solitary slow-growing mass in the cervical region. Histopathology revealed multifocal to coalescing single or clusters of blood-filled vessels lined by flattened endothelial cells with narrow, elongated, basophilic nuclei. These regions were embedded in adipose tissue with multifocal areas of intervascular remnants of differentiated serous salivary glandular tissue with multifocal small ducts. Fibrin thrombi occupied a few of the vessel lumens. A histological diagnosis of infiltrative angiolipoma was made. On computed tomography, the mass was bilobed with a suspected primary component involving the right parotid gland which was grossly enlarged. The mass had a slightly hypoattenuating mottled to lobulated appearance with a few hyperattenuating mineralised specks throughout. Hounsfield units of the mass ranged between 40 and 45, which was less than the 60-65 of the contralateral salivary glands and cranial musculature. Post contrast images showed no contrast enhancement of 90% of the mass with only a band of peripheral contrast uptake of the affected lateral lobe.
Highlights
According to the World Health Organisation (WHO) classification of mesenchymal soft tissue tumours in domestic animals, benign tumours originating from adipose tissue can be divided into lipomata and angiolipomata[7]
In contrast to domestic animals, 14 types of benign tumours of adipose tissue are recognised in humans[4]
Angiolipomata reported in dogs include 2 variants and are classified as infiltrative or non-infiltrative, as is done for lipomata[10,19]
Summary
According to the World Health Organisation (WHO) classification of mesenchymal soft tissue tumours in domestic animals, benign tumours originating from adipose tissue can be divided into lipomata (with a sub classification of infiltrative lipomata) and angiolipomata[7]. Examination of haematoxylin & eosinstained, routinely prepared sections by light microscopy revealed multifocal to coalescing single or clusters of blood-filled vessels lined by flattened endothelial cells with narrow, elongated, basophilic nuclei; occasional nuclei were slightly plump These regions were surrounded by and embedded in adipose tissue and there was a thin intervascular fibrous connective tissue stroma. Made 5 minutes after contrast injection showed no contrast enhancement of 90 % of the mass with only a band of contrast uptake on the ventral, lateral and dorsal aspect of the affected lateral lobe (Fig. 4 a,b) This appeared to be consistent with normal salivary tissue as the normal salivary glands uptake had a similar HU. 14 months after diagnosis the dog is reported to be doing well the mass has increased in size by approximately 30 %
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