Abstract
While gastric cancer is a well established angiogenesis driven tumor, no data has been published regarding angiogenesis stimulated by mast cells (MCs) positive for tryptase in bone metastases from gastric cancer patients (BMGCP). It is well established that MCs play a role in immune responses and more recently it was demonstrated that MCs have been involved in tumor angiogenesis. We analyzed infiltrating MCs and neovascularization in BMGCP diagnosed by histology. A series of 15 stage T3-4N2-3M1 (by AJCC for Gastric Cancer Staging 7th Edition) BMGCP from bone biopsies were selected. Tumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of MCs density positive to tryptase (MCDPT), MCs area positive to tryptase (MCAPT), microvascular density (MVD) and endothelial area (EA). A significant correlation between MCDPT, MCAPT, MVD and EA groups to each other was found by Pearson and t-test analysis (r ranged from 0.68 to 0.82; p-value ranged from 0.00 to 0.02). Our very preliminary data suggest that infiltrating MCs positive for tryptase may play a role in BMGCP angiogenesis, and could be further evaluated as a novel target of anti-angiogenic therapy.
Highlights
Gastric cancer is an important cause of cancer-related mortality [1,2]
Mean values ± 1 standard deviations (SD) of all the tissue-evaluated parameters are reported in microvascular density (MVD) (r = 0.82, p = 0.00), between MCs density positive to tryptase (MCDPT) and MCs area positive to tryptase (MCAPT) (r = 0,77, p = 0.01), between MCDPT and endothelial area (EA) (r = 0.73, p = 0.01), between MCAPT and MVD (r = 0.68, p = 0.02), between MCAPT and EA
From an immunological point of view, mast cells (MCs) positive to tryptase are involved in several inflammatory and immediate allergic Immunoglobulin E (IgE)-mediated reactions [8,42]
Summary
Gastric cancer is an important cause of cancer-related mortality [1,2]. At the time of diagnosis, the majority of the patients usually have unresectable or metastatic disease [1]. Gastric cancer is a well established angiogenic driven tumor and its metastatic process is supported by angiogenesis [4,5] no data have been published regarding the correlation between angiogenesis and mast cells (MCs) in bone metastases from gastric cancer patients (BMGCP). MCs are abundant in locations that are exposed to the outside world, such as lung, gastrointestinal tract and skin [6,7]. Since they take up permanent residence in these locations, they are always on hand to respond to infections that most commonly occur during wounding [8]. When IgE-coated antigens bind to surface receptors, MC degranulation occurs [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
