Infertility patients with chromosome inversions are susceptible to an inter-chromosomal effect

Abstract

Inversions are structural chromosome abnormalities that are associated with infertility due to the increased risk of producing unbalanced gametes from recombination events within the inverted chromosome segment. However, there is also evidence indicating the presence of an inter-chromosomal effect during chromosome segregation influencing the generation of other chromosome aneuploidies. The aim of this study was to evaluate the nature of chromosome errors in IVF blastocysts from carriers of balanced chromosome inversions.