Inferring Postimplant Dosimetry and Determining Radiation Dose Cold Spots Using Images Obtained at Time of Recurrence After Permanent Prostate Implant Brachytherapy: A Pragmatic Study

Abstract

Purpose: Nearly 30% of the patients (Pts) with a clinically localized prostate cancer who underwent a primary permanent prostate implantation (PPI) have a biochemical failure. Hypothesizing that the recurrence could be correlated with the “cold” areas on the preoperative or postoperative PPI dosimetric plans, the purpose of this work is to a) compensate volume change and project the MR based dose distribution back to the time of post-implant assessment, b) identify cold spots and c) infer the cause for failure.