Inferring Group-Wise Consistent Multimodal Brain Networks via Multi-view Spectral Clustering

Abstract

Quantitative modeling and analysis of structural and functional brain networks based on diffusion tensor imaging (DTI)/functional MRI (fMRI) data has received extensive interest recently. However, the regularity of these structural or functional brain networks across multiple neuroimaging modalities and across individuals is largely unknown. This paper presents a novel approach to infer group-wise consistent brain sub-networks from multimodal DTI/fMRI datasets via multi-view spectral clustering of cortical networks, which were constructed on our recently developed and extensively validated large-scale cortical landmarks. We applied the proposed algorithm on 80 multimodal structural and functional brain networks of 40 healthy subjects, and obtained consistent multimodal brain sub-networks within the group. Our experiments demonstrated that the derived brain sub-networks have improved inter-modality and inter-subject consistency.