Abstract
In Reply .— The Montelukast Study of Asthma in Children (MOSAIC) clinical trial1 is one of the first long-term (12 months of treatment) and large ( n = 994) studies comparing the relative benefit of an oral leukotriene-receptor antagonist (montelukast) and an inhaled corticosteroid (fluticasone) in asthma control in children. This was a noninferiority study of children with mild persistent asthma, with the percent asthma rescue-free days (RFDs) as the primary end point. This end point measures any day during which the patient did not use asthma rescue medication (such as an inhaled β-agonist or an oral …
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