Abstract
Ribonucleic acid preparations, isolated from poliomyelitis virus-infected hamster brain and spinal cord and from Ehrlich ascites tumor cells infected with West Nile encephalitis virus have been shown to be infectious. The infectious components in the ribonucleic acid preparations and the corresponding virus particles were differentiated on the basis of lability to ribonuclease and incubation at 37°;, by their behavior in 1 M sodium chloride solution, and by differences in their sedimentation velocities. Poliomyelitis and West Nile viruses were isolated from the brains of mice which died following the intracerebral injection of the corresponding ribonucleic acid preparations, and were identified by means of specific immune sera. Data are presented which indicate that in the case of ribonucleic acid preparations isolated from Mengo encephalitis virus-infected Ehrlich tumor cells, the infectious component arises from intact virus particles.
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