Infectivity of Murine SK Strain of Poliomyelitis Virus.

Abstract

SummaryObservations are reported on the infectivity of the murine SK strain for mice based on certain types of exposure to the virus. Some of the infected mice were embedded in toto, sectioned, and examined histologically for evidence of virus multiplication in non-nervous as well as nervous tissue. Although infections occurred readily under various types of exposures to the virus, no lesions suggestive of virus activity were observed in any tissues or organs apart from the CNS. Infections by the intranasal route could not be prevented by prior intranasal instillations of zinc sulphate solution used to block the olfactory pathway as a portal of entry. Mice could be readily infected with virus-contaminated drinking water. Virus cultivated in developing eggs proved less infectious for mice when supplied to the animals in drinking water or food than mouse brain-cord virus suspensions. Old mice showed themselves less susceptible than young mice to certain types of exposure, but to other types of exposure the ...