Abstract
A subviral fraction of influenza particles, free of intact infectious particles and containing only viral RNA, nucleoprotein, and two minor P proteins (RNP+P) has been shown to be infectious in suitably treated chick embryo fibroblasts. Infection required the cooperation of at least seven segments of RNP+P, and infectivity was readily destroyed by RNAse, pronase, or reagents which remove the P proteins. Similar subviral preparations were shown to be capable of rescuing temperature-sensitive mutants of influenza virus and ts mutants belonging to different complementation groups were preferentially rescued by different size classes of RNP+P complexes. The evidence suggests that rescue of one prototype mutant strain was accomplished by one segment of RNP+P and that of another strain by two segments.
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