Abstract
AbstractSequential immunologic, cytochemical, and cytokinetic studies were done on single lymphoid cells in the peripheral blood of 6 children with infectious mononucleosis (IM) and 1 child with toxoplasmosis 1–2 wk after onset of symptomatology. The absolute number of AET-SRBC rosetting (E+) cells was increased in all patients; the absolute number of cells with surface IgM (sIgM+) was increased in 3 of 7 patients. On the average, 46% of all lymphoid cells were E+Ia+sIgM−, 35% E+Ia− sIgM−, and 5% E−Ia+sIgM+. Of the E+Ia+sIgM− cells, only 7% were shown to have a dot-like esterase reaction pattern. Of the E+Ia−sIgM cells, 17% were esterase positive. The mean labeling index of the former was 18.2%, the mean labeling index of the latter 4.4%. No proliferating sIgM4 cells were observed in the 6 children with IM. The esterase reactions and the labeling indices of suppressor-cytotoxic and inducer-helper T cells were similar to those of E+Ia−sIgM− and E+la−sIgM− cells, respectively. These results suggest that the vast majority of the atypical cells in IM corresponds to activated suppressor cells, while a minority appears to be proliferating helper cells.
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