Abstract

We agree with the opinion of Tamir et al.1 that the Paul-Bunnell and mononucleosis tests are of little value in children. In Japan, infectious mononucleosis is not common. Illness caused by Epstein-Barr virus (EBV) infection is rare after infancy because the positive antibody sera to EBV is 30% to 40% in the sera of infants between 1 and 24 months old. This increases rapidly to about 80% by 3 years of age.2 Primary EBV infection may occur before the age of 3 years.

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