Abstract
Sera taken before illness and during convalescence from patients with infectious mononucleosis (IM) were examined for their ability to neutralize the capacity of Epstein-Barr virus (EBV) to stimulate formation of lymphoblastoid cell lines from human leukocytes in vitro. Neutralizing activity was not detected in 13 of 15 sera taken before illness and was present at a dilution of 1:4 or higher in all of 24 sera taken after illness. EBV-neutralizing activity was found in sera collected during the first week of illness and was also demonstrated in a serum obtained many years after illness. The titer of neutralizing activity in sera of two patients studied sequentially did not change significantly during the first year after IM. The results demonstrate appearance of EBV-neutralizing antibody in IM and support previous seroepidemiologic studies which indicate that EBV is the etiologic agent of IM.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
