Abstract
A previously unreported afebrile, infectious leukoencephalomyelitis of one- to four-month-old dairy goats was studied. The disease was characterized by pleocytosis and posterior ataxia that progressed to complete paralysis within two weeks of onset. Dense perivenous accumulations of lymphoreticular cells in white matter and variable myelinoclasis were the essential neuropathologic lesions. These were accompanied by mild interstitial pneumonia and hyperplasia of pulmonary lymphoid tissue. Epizootiologic observations suggest that goats become infected either in utero or immediately after birth. The disease was transmitted to newborn goats by intracerebral and intraperitoneal inoculation of a 220-nm millipore filtrate of nervous tissue from a naturally infected goat. This observation and the failure to isolate bacteria or mycoplasma suggest that the causative agent is a virus, which thus far appears to be serologically unrelated to other animal viruses. The nature of the neuropathologic changes suggests that this disease may share pathogenic mechanisms with postinfectiolls encephalitis of man.
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