Abstract
Infectious disease aerobiology: miasma incarnate
Highlights
There is an exceedingly small group of microorganisms that are considered pathogenic in humans relative to the microbial biota—with literally just a few bacterial and viral agents that have the potential to cause disease when transmitted in aerosol form
The nature of the aerosol source can be determinative of the size distribution of the pathogenic aerosols and affect the pattern of initial deposition in the respiratory system and the tissue/cell types most impacted by the pathogen
The resulting disease models have shown utility in medical product evaluations targeted to protecting or ameliorating the effects from an infectious mucosal/aerosol challenge. These aerosol disease models have been and continue to be an especially important consideration in biodefense-related research studies. This special issue brings together 11 articles that are diverse in content but are unified under a central theme of infectious disease aerobiology
Summary
There is an exceedingly small group of microorganisms that are considered pathogenic in humans relative to the microbial biota—with literally just a few bacterial and viral agents that have the potential to cause disease when transmitted in aerosol form. The complexity of the mucosal response to infection within the respiratory system is affected by the number of infectious particles deposited, but the relative integrity of the microbial constituents contained in the aerosol particles. The resulting disease models have shown utility in medical product evaluations targeted to protecting or ameliorating the effects from an infectious mucosal/aerosol challenge.
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