Infectious Causes of Neoplasia in the Domestic Cat.

Abstract

Simple SummaryIncreasingly, cancers are being linked to infections with viruses, bacteria, and parasites in human medicine. This review summarises the current literature regarding neoplasia occurring in association with infectious diseases in domestic cats. To date, most studies have focused on the role of viruses, especially feline leukaemia virus and feline immunodeficiency virus in association with lymphoma, or the role of papillomavirus in cutaneous and oral neoplasms in cats. Recently, there has been a focus on a potential role of mouse mammary tumour virus in feline mammary carcinoma and lymphoma and studies assessing the potential role of gammaherpes virus and hepadnaviruses in feline neoplasia. Additionally, there has been some focus on potential bacterial and parasitic associations with neoplasia; including reports assessing potential associations between Helicobacter species and gastrointestinal neoplasms, and case reports of neoplasia in association with Platynosomum fastosum and Opisthorchis viverrini.In recent years, growing attention has been paid to the influence/role of infectious diseases in tumour development and progression. Investigations have demonstrated that some infectious organisms can have a direct role in the development of neoplasia, whereas others can predispose to neoplasia by alterations in the immune response, or by creating a pro-inflammatory environment. Feline leukaemia virus was one of the first infectious agents recognised as an oncogenic organism, and along with feline immunodeficiency virus has received the most attention. Since the discovery of this retrovirus, several other organisms have been associated with neoplastic processes in cats, these include gammaherpes virus, mouse mammary tumour virus, papillomaviruses, hepadnavirus, Helicobacter species, and the parasitic infections Platynosomum fastosum and Opisthorchis viverrini. This review summarises the findings to date.