Abstract
Infection with Mycobacterium lepromatosis.
Highlights
Sequencing of the full M. leprae genome[1] ushered in a new era in the microbiology of this disease, and it was not long before molecular studies identified a genetically similar organism associated with leprosy, dubbed “Mycobacterium lepromatosis.”[2]
The report in this issue by Sotiriou and others[3], of M. lepromatosis infection in two siblings, provides the best clinical descriptions to date of the syndrome caused by this organism, which appears to be clinically equivalent in all respects to the classical disease, leprosy
Based on the limited experience of the National Hansen’s Disease Programs (NHDP) with the treatment and follow-up of a small number of patients with this infection in the United States and Canada, it appears that infection with M. lepromatosis manifests clinically and histologically with a wide spectrum of lesions that is well described in leprosy
Summary
The report in this issue by Sotiriou and others (two cases of leprosy in siblings caused by M. lepromatosis and review of the literature)[3], of M. lepromatosis infection in two siblings, provides the best clinical descriptions to date of the syndrome caused by this organism, which appears to be clinically equivalent in all respects to the classical disease, leprosy. Sequencing of the full M. leprae genome[1] ushered in a new era in the microbiology of this disease, and it was not long before molecular studies identified a genetically similar organism associated with leprosy, dubbed “Mycobacterium lepromatosis.”[2]
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