Infection of Helicobacter pylori in gastric - cardia cancerous lesions:a comparative study between the high - and - low risk populations

Abstract

Objective To further elucidate the possible relationship between infection of Helicobacter pylori(Hp)and gastric cardia carcinogenesis on the subjects from HIA and LIA for GCC.Methods Helicobacter pylori Kit were undertaken to determine the expression of Hp in gastric cardia carcinogenesis.Two hundred and sixty -two surgical resected GCA specimens were selected randomly from the hospital(161 from the HIA, 101 from the LIA).Results The ratio of Hp infection of the gastric - cardia adenocarcinoma was 49% and 48% in high and low - incidence areas for gastric cardia carcinogenesis (P ＞ 0.05).However, in high and low - incidence area, the rate of Hp infectiion of GCA in male was higher than in females and the older was higher than the young.The ratio of Hp infection of FH(+)in high - incidence area was apparently higher than that in the low - incidence area.However, in the LIA,the rate of Hp infection of FH(+)was apparently higher than the Hp infection of FH(-), P ＜ 0.05.Conclusions The affectability of GCA of Hp infection is low.Hp infection is correlated with the carcinogenesis and development of cardiac cancer in high and low - incidence area. Key words: Gastric - cardia adenocarcinoma ; Helicobacter pylori ; High - incidence area ; Low - incidence area ;