Infection of chicks by intranasal route with Rous sarcoma virus.

Abstract

Summary and Conclusions1. It is possible to infect chicks with the Rous sarcoma virus by using the intranasal route. 2. By this route, the lungs always became involved if infection took place, but growths were by no means limited to this organ. 3. Widespread involvement of organs and tissues may result from inoculation by this route. 4. Inhalation of aerosol preparations of the Rous virus did not yield recognizable Rous virus infection in this study. 5. The organs and tissues involved with sarcoma in some instances were those not usually associated with Rous infection when other routes of inoculation are used. 6. No hemorrhagic disease was observed in infected chicks. 7. The possible relationship of the intranasal route to the method of spread of natural Rous virus infection is considered as is also the bearing of these experiments on cancer in general.