Abstract
Mouse hepatitis virus type-4 (strain JHM) has extensively been studied as a causative agent of virus-induced demyelinating disease in mice and rats (1). Infection of mice with MHV-4 may result in fatal encephalomyelitis, with infection of all central nervous system cell types, or it may pathologically be limited to demyelination (2). There typically is little perivascular inflammation with MHV-4 infection in the mouse, although infiltrating macrophages and demyelination are found (3). Furthermore, MHV-4 demyelination is commonly followed by extensive remyelination (4, 5). This pattern is contrasted to experimental allergic encephalomyelitis (EAE) and Theiler’s mouse encephalomyelitis virus (TMEV)-induced demyelination, with perivascular lymphocytic and macrophage cuffing and infiltration but little remyelination (6). The paucity of infiltrating lymphocytes in MHV-4 infection may reflect viral perturbation of lymphocyte function (7).KeywordsDemyelinating DiseaseExperimental Allergic EncephalomyelitisThymic Epithelial CellMouse Hepatitis VirusPerivascular InflammationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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