Abstract
When rabbits, guinea pigs, and hamsters are inoculated intracutaneously with small doses of infectious peritoneal exudates, an indurated popular lesion develops which lasts few days and then regresses to disappear completely. We have no evidence on the possible distribution of the agent following the intracutaneous inoculation. When these animals are subsequently challenged by the inoculation of infectious material, they are shown to possess a solid immunity, while the controls show signs of active disease or die. These experiments fit in with observations made by others as well as by us, namely, that an active immunity against scrub typhus in the experimental animal can be induced.
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