Abstract
A new mouse monoclonal antibody that recognizes α- and β-heavy chains of human atrial and ventricular myosin and β-heavy chain of human slow skeletal muscle myosin was obtained. The 125I- and 111In-labelled antibody, and its F(ab′) 2 and Fab fragments localize in isoproterenol induced infarcted rat heart, with the F(ab′) 2 fragment showing the highest uptake. Comparison with 99mTc-pyrophosphate uptake in infarcted dog heart, induced by selective obstruction of a coronary artery, suggest that the 111In-labelled F(ab′) 2 localizes specifically in infarcted myocardium only.
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Schedule a callMore From: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
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