Abstract
We aim to explore tissue heterogeneity assessment using T1 maps generated with the modified Look Locker (MOLLI) sequence in patients with previous myocardial infarct. Conclusion: Differences between healthy myocardium and scarred tissues can be reliably distinguished from the R1 values derived from pre-contrast T1 maps.Potentially, patients without scarred myocardium do not need post-contrast imaging. Inpatients with scarred tissues, ΔR1 value derived from both thepre- and the post-contrast T1 maps provides better distinction between grey zone and scar core than either pre-contrast or post-contrast R1 value alone.
Highlights
Cardiac magnetic resonance imaging with late gadolinium enhancement (LGE-CMR) has been the standard tool for assessing regional fibrosis
Infarct myocardium tissue heterogeneity assessment using pre-contrast and post-contrast T1 maps acquired with Modified Look-Locker Inversion Recovery (MOLLI) imaging
Differences between healthy myocardium and scarred tissues can be reliably distinguished from the R1 values derived from pre-contrast T1 maps
Summary
Cardiac magnetic resonance imaging with late gadolinium enhancement (LGE-CMR) has been the standard tool for assessing regional fibrosis. Tissue heterogeneity quantification by traditional signal-intensity (SI-) based methods is not without limitations. T1 relaxation-time mapping allows direct myocardial signal quantification and enables true quantitative characterisation of myocardial tissue heterogeneity. We aim to explore tissue heterogeneity assessment using T1 maps generated with the modified Look Locker (MOLLI) sequence in patients with previous myocardial infarct
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